Population
Isolated guinea pig atria, guinea pig ventricular strips, and sheep Purkinje fibers
Comparison
Propafenon (0.5 to 1 microgram/ml) vs Baseline and verapamil
Design
Preclinical
Authors
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Does not guide clinical propafenone use; leaves open mechanistic translation from guinea pig atria to human arrhythmias.
Propafenon acts as an antiarrhythmic agent primarily through membrane stabilizing and beta-blocking effects at low concentrations, with minimal calcium channel blockade.
Ledda et al. (1981) studied this question.
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