Key result
Cilnidipine 5 mg daily induced bilateral pitting ankle edema in a 40-year-old male after 6 weeks of therapy, which resolved completely 14 days after drug discontinuation.
Case Report (n=1)
No
Cilnidipine, despite being proposed as an alternative for amlodipine-induced edema, can also cause ankle edema.
Answers are grounded in this paper and cite their sources.
Cilnidipine may cause ankle edema; challenges its proposed advantage over amlodipine and leaves open comparative safety data.
Cilnidipine is a 4(th) generation dihydropyridine calcium channel blocker approved recently for the treatment of essential hypertension. It is not known to present with ankle edema like amlodipine. Moreover, it has been proposed as an alternative anti-hypertensive for patients with amlodipine-induced edema. We report a case of cilnidipine induced ankle edema.
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Annil et al. (2014) conducted a case report in Hypertension (n=1). Cilnidipine was evaluated on Development of ankle edema. Cilnidipine 5 mg daily induced bilateral pitting ankle edema in a 40-year-old male after 6 weeks of therapy, which resolved completely 14 days after drug discontinuation.
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