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Design
Review
Hypothesis-generating for lineage-targeted regeneration; leaves open clinical translation pending functional human studies.
The heart beat is coordinated by the integrated activities of three myocyte subpopulations: atrial myocytes, ventricular myocytes, and cells of the cardiac conduction system. In this review we discuss the classic fate map and recent retroviral cell lineage studies to better understand the origin, timing, and mechanisms regulating (a) the formation of these three myocyte lineages and (b) the morphogenetic plan underlying formation of the myocardial walls and the conduction system.
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Mikawa et al. (1996) studied this question.
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