February 1, 1996Cardiovascular Research

Distribution of connective tissue proteins during development and neovascularization of the epicardium

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Population

Embryonic chicken hearts

Design

Preclinical

Authors

DBDavid BoucheyMedical University of South Carolina CDChristopher J. DrakeMedical University of South Carolina AWAmanda M. WunschOregon Health & Science University

Discussion

Member takes

Implication

Animal data implicate matrix proteins in coronary ontogeny; leaves open relevance to human disease or repair.

Structured PICO

Population

Embryonic chicken hearts

Intervention

Immunofluorescence microscopy and immunoblot analysis of extracellular matrix proteins (vitronectin, fibronectin, JB3 antigen)

Outcome

Distribution of vitronectin, fibronectin, and JB3 antigen during epicardial development and coronary neovascularizationsurrogate

The JB3 antigen may serve as an early marker for maturing coronary arteries, while vitronectin and fibronectin are involved in epicardial cell migration and remodeling during embryonic development.

Cite This Study

Bouchey et al. (1996) studied this question.

synapsesocial.com/papers/6a8591b6afd961f1253daf4e https://doi.org/10.1016/s0008-6363(95)00109-3

View Full Paper

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Distribution of connective tissue proteins during development and neovascularization of the epicardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Distribution of connective tissue proteins during development and neovascularization of the epicardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider