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Coprecipitates of morphine were prepared by using EudragitR L30D as a carrier in order to obtain controlled release dosage systems. Differential Scanning Calorimetry and IR, 1H- and 13C-NMR spectroscopies were applied in order to explain the mechanism of this interaction. The results obtained indicated that there was an intermolecular association between the polymer and the drug consisting in two different hydrogen bonds interactions. The proposed reaction involves coprecipitates having morphine contents greater than 50%.
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Arévalo et al. (1994) studied this question.
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