Answers are grounded in this paper and cite their sources.
[reaction: see text] A base-induced ring opening/imine isomerization/diastereoselective organometallic addition sequence on 4-substituted 2-perfluoroalkyl-1,3-oxazolidines has been developed for the asymmetric synthesis of aryl alpha-perfluoroalkylamine derivatives. This practical method provides chiral amino alcohols in 60-95% yield with uniformely high diastereoselectivities ranging from 35:1 to >100:1.
No takes yet. Share an insight, caveat, or question.
Gosselin et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: