Key result
Cardiac-specific up-regulation of calreticulin in adult mice induced dilated cardiomyopathy, significantly reducing left ventricular ejection fraction to 30.8% compared to 64.5% in controls.
Why the study?
Does up-regulated expression of calreticulin induce cardiomyopathy in adult mice?
Population
8-10 week-old male C57BL/6 mice carrying aMHC/CAT-loxP-CRT transgenes (n=33 in echocardiography analysis)
Comparison
Tamoxifen-induced up-regulation of calreticulin… vs CAT-loxP-CRT mice fed tamoxifen and…
Design
Preclinical
Follow-up
3 weeks
Authors
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Supports calreticulin up-regulation as a driver of adult cardiomyopathy; leaves open human translation and therapeutic targeting.
Does up-regulated expression of calreticulin induce cardiomyopathy in adult mice?
Absolute Event Rate: 30.8% vs 64.5%
p-value: p=<0.01
Up-regulation of the endoplasmic reticulum chaperone calreticulin in the adult heart induces dilated cardiomyopathy and heart failure by altering Ca2+ handling proteins and gap junctions.
Lee et al. (2013) studied Dilated cardiomyopathy (n=33). Cardiac-specific calreticulin up-regulation vs. Control mice with tamoxifen induction was evaluated on Left ventricular ejection fraction (%EF) (p=<0.01). Cardiac-specific up-regulation of calreticulin in adult mice induced dilated cardiomyopathy, significantly reducing left ventricular ejection fraction to 30.8% compared to 64.5% in controls.
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