Why the study?
Does a combined regime of a monoamine oxidase inhibitor and 9-alpha-fluorohydrocortisone improve symptoms in a patient with idiopathic orthostatic hypotension and autonomic failure?
Does a combined regime of a monoamine oxidase inhibitor and 9-alpha-fluorohydrocortisone improve symptoms in a patient with idiopathic orthostatic hypotension and autonomic failure?
A combination of a monoamine oxidase inhibitor and 9-alpha-fluorohydrocortisone can alleviate symptoms of orthostatic hypotension but requires close supervision due to the risk of supine hypertension.
May warrant cautious trial in refractory orthostatic hypotension with supine BP monitoring; leaves open need for controlled trials.
A case of orthostatic hypotension with autonomic failure is presented, and the patient's clinical response to the combined regime of a monoamine oxidase inhibitor and 9-alpha-fluorohydrocortisone is discussed. This therapy provided a relatively convenient means of alleviating the patient's symptoms and appears to be of considerable value in the management of orthostatic hypotension. However, close patient supervision is essential when these drugs are used as they cause hypertension in the supine position in subjects with poor baroreceptor function.
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Mahar et al. (1975) studied this question.
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