The Nephrotoxic Lesion of Ethylene Glycol

Case Reports1 March 1957THE NEPHROTOXIC LESION OF ETHYLENE GLYCOLLEONARD B. BERMAN, M.D., GEORGE E. SCHREINER, M.D., JEAN FEYS, M.D.LEONARD B. BERMAN, M.D., GEORGE E. SCHREINER, M.D., JEAN FEYS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-3-611 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeedle biopsy of the kidney affords a unique opportunity to study the pathology of renal disease in the living patient.1 This relatively new and valuable investigative tool was employed in one of two recently observed nonfatal cases of acute renal insufficiency due to ethylene glycol. The demonstration of oxalate crystals in the renal tubules represents the first reported premortem confirmation of a finding well established in autopsy material.2 Observations on additional histologic changes and clinical course manifested by these patients may be of sufficient interest to warrant a description and brief review of ethylene glycol toxicity.Ethylene glycol was first...Bibliography1. KarkMuehrckePiraniPollak RMRCCLVE: The clinical value of renal biopsy, Ann. Int. Med. 43: 807-847, 1955. LinkGoogle Scholar2. PonsCuster CARP: Acute ethylene glycol poisoning: clinico-pathologic report of 18 fatal cases, Am. J. M. Sc. 211: 544-552, 1946. CrossrefMedlineGoogle Scholar3. LangCalveryMorrisWoodward EPHOHJG: Toxicology of some glycols and derivatives, J. Ind. Hyg. and Toxicol. 21: 173-201, 1939. Google Scholar4. SmythSeatonFischer HFJL: Single dose toxicity of some glycols and derivatives, J. Ind. Hyg. and Toxicol. 23: 259-268, 1941. Google Scholar5. 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SternheimerMalbin RB: Clinical recognition of pyelonephritis, with new stain for urinary sediments, Am. J. Med. 11: 312-323, 1951. CrossrefMedlineGoogle Scholar13. Schreiner GE: The treatment of acute renal insufficiency, M. Ann. District of Columbia 22: 531-535, 1953. MedlineGoogle Scholar14. Smith HW: The kidney, structure and function in health and disease, 1951, Oxford University Press, New York. Google Scholar15. HagemannChifelle POTR: Ethylene glycol poisoning, clinical and pathologic study of 3 cases, J. Lab. and Clin. Med. 33: 573-584, 1948. MedlineGoogle Scholar16. GeilingCannon EMRR: Pathologic effects of elixir sulfanilamide (diethylene glycol) poisoning; clinical and experimental correlation: final report, J. A. M. A. 111: 919-926, 1938. CrossrefGoogle Scholar17. Oliver J: Correlations of structure and function and mechanisms of recovery in acute tubular necrosis, Am. J. Med. 15: 535-557, 1953. CrossrefMedlineGoogle Scholar18. JeghersMurphy HR: Practical aspects of oxalate metabolism, New England J. Med. 233: 208-215, 238-246, 1945. CrossrefGoogle Scholar19. SchreinerBerman GELB: The clinical spectrum of postpartum acute renal insufficiency, Ann. Int. Med. 43: 1230-1240, 1955. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication December 14, 1955.From the Department of Medicine, Georgetown University Hospital, Washington, D. C.This work was supported in part by the Georgetown University Kidney Research Fund, and a grant from the Hartford Foundation.Requests for reprints should be addressed to George E. Schreiner, M.D., Georgetown University Hospital, Renal Laboratory, Washington 7, D. C. 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Schreiner, M.D.Ethylene Glycol, Methanol and Isopropyl Alcohol IntoxicationEarly and Late Presentations of Ethylene Glycol PoisoningPreliminary validation of a point-of-care ethylene glycol test for catsMethanol, Ethylene Glycol, and Other Toxic AlcoholsTwo Cases of Rapid Onset Parkinson's Syndrome Following Toxic Ingestion of Ethylene Glycol and MethanolHyperosmolality: Another Indication for Hemodialysis Following Acute Ethylene Glycol PoisoningEXPERIENCES OF THE CZECH TOXICOLOGICAL INFORMATION CENTRE WITH ETHYLENE GLYCOL POISONINGEthylene Glycol Exposure: an Evidence-Based Consensus Guideline for Out-of-Hospital ManagementAcute ethylene glycol toxicosis in a horseFomepizole as an Antidote for Ethylene Glycol PoisoningCurrent Management of Ethylene Glycol PoisoningAmerican Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol PoisoningAntidotes for acute poisoning and intoxicationEthylene glycol poisoning: Case report of a record-high level and a reviewAntidotes for Methanol and Ethylene Glycol PoisoningDrug- and Toxin-Induced SeizuresEthylene glycol antifreeze poisoning Three case reports and a review of treatmentPoisonings & IntoxicationsTransport Management of the Patient With Acute PoisoningEthylene Glycol IntoxicationSystemic Therapeutic Agents and Retinal ToxicityThe Other AlcoholsAcute Renal Failure Due to Urinary Tract ObstructionUrine fluorescence using a wood's lamp to detect the antifreeze additive sodium fluorescein: A qualitative adjunctive test in suspected ethylene glycol ingestionsSubacute and Subchronic Toxicity of Ethylene Glycol Administered in Drinking Water to Sprague-Dawley RatsThe Nephrotoxic Potential of Drugs and Chemicals Pharmacological Basis and Clinical RelevanceAcute Intoxication by Ethylene-Glycol and MethanolMassive ethylene glycol poisoning without evidence of crystalluria: A case for early interventionEthylene GlycolAcute Metabolic Acid-Base DisordersEthylene Glycol IntoxicationAdult respiratory distress syndrome secondary to ethylene glycol ingestionSentinel Health Events (Occupational): A Basis for Physician Recognition and Public Health SurveillanceSentinel Health Events (occupational): a basis for physician recognition and public health surveillance.Ethylene glycol poisoningSECONDARY RENAL OXALOSISDose‐dependent disposition of ethylene glycol in the rat after intravenous administrationOphthalmic manifestations of primary oxalosis.STRUCTURE SIDE-EFFECT SORTING OF DRUGS.Monohydrate Calcium Oxalate Crystalluria in Ethylene Glycol PoisoningThe effect of pyrazole on ethylene glycol toxicity and metabolism in the ratEthylene and Diethylene Glycol ToxicityOn the metabolic acidosis of ethylene glycol intoxicationEthylene glycol poisoningEthylene glycol poisoningThe Spectrum of Ethylene Glycol PoisoningThe effect of partial hepatectomy on the toxicity of ethylene glycol, glycolic acid, glyoxylic acid and glycineThe inhibition of oxalate biosynthesis in isolated perfused rat liver by dl-phenyllactate and n-heptanoateAcquired Hyperoxaluria, Nephrolithiasis, and Intestinal DiseaseHormonal Influences Upon Ethylene Glycol PoisoningHerzerkrankung bei primärer OxaloseAkutes NierenversagenBegutachtung der NierenerkrankungenAcute Ethylene Glycol Poisoning: Report of a Fatal CaseToxic nephropathyEthylene-glycol Poisoning Treated by HaemodialysisDas urologische ZusammenhangsgutachtenConsequences of ethylene glycol poisoningOxaloseToxic Solvents: A Review 1 March 1957Volume 46, Issue 3Page: 611-619KeywordsCalciumEthyleneHospital medicineKidneysLesionsNecrosisPathogenesisRenal diseasesResearch fundingToxicity ePublished: 1 December 2008 Issue Published: 1 March 1957 PDF downloadLoading ...