Key result
An aortic propagation velocity cutoff of 60 cm/sec predicted the presence of coronary artery disease with an area under the curve of 0.813, 72.5% sensitivity, and 62% specificity.
Why the study?
Optimal risk stratification in coronary artery disease is critical, and aortic propagation velocity may reflect increasing vascular stiffness, but its correlation with the presence and severity of CAD required investigation.
Does Aortic Propagation Velocity (APV) correlate with the presence and severity of coronary artery disease in patients presenting with acute coronary syndrome?
Observational (n=100)
Does Aortic Propagation Velocity (APV) correlate with the presence and severity of coronary artery disease in patients presenting with acute coronary syndrome?
Answers are grounded in this paper and cite their sources.
Aortic propagation velocity is a simple, noninvasive echocardiographic parameter that correlates significantly with the presence and angiographic severity of coronary artery disease.
Background: Optimal risk stratification of patients with coronary artery disease (CAD) is of paramount importance to deliver appropriate care. As the age increases and with an increase in risk factors for CAD, the stiffness of the vascular system increases. The aortic propagation velocity (APV) may decrease with an increase in the stiffness and decrease in the strain and distensibility. Aim: To correlate the Aortic Propagation Velocity (APV) with the presence and severity of CAD. Subjects and Methods: Patients with diagnosis of Acute coronary syndrome (ACS) have been enrolled. APV, Aortic strain (AS) and aortic distensbility (AD) have been assessed in them. The correlation of the parameters with severity of CAD was assessed. Results: A total of 100 consecutive patients were studied. The patients were divided into two groups after coronary angiography (Group A – with CAD and Group B – normal coronaries). The male-to-female ratio in the whole cohort was 2.3:1. The mean age of presentation for Group A was 54 ± 10.8 years and for Group B was 51.1 ± 7.37 years ( t = 1.56, P = 0.122). The AS, AD, and APV were significantly decreased in patients with CAD ( P < 0.0001). There was significant decrease in APV as there is increase in syntax score (SS) (SS <22 [20] – 65.15 ± 9.25 vs. SS 22–32 [16] – 55.88 ± 10.14 vs. SS >32 [14] – 37.09 ± 8.02, respectively, P < 0.0001). On receiver operating characteristic curve analysis, the cutoff of APV for the prediction of CAD was 60 cm/sec (area under the curve: 0.813) with a sensitivity of 72.5% and specificity of 62%. Conclusion: APV is a reliable, simple echocardiographic parameter of aortic stiffness which is feasible for noninvasive cardiovascular risk stratification during the evaluation of CAD.
No takes yet. Share an insight, caveat, or question.
Vamsikrishna et al. (2020) conducted an observational in Acute coronary syndrome (ACS) (n=100). Aortic Propagation Velocity (APV) vs. Normal coronaries was evaluated on Presence of CAD (AUC 0.813, p=< 0.0001). An aortic propagation velocity cutoff of 60 cm/sec predicted the presence of coronary artery disease with an area under the curve of 0.813, 72.5% sensitivity, and 62% specificity.
Synapse has enriched 10 related papers. Consider them for comparative context: