Aortic propagation velocity in patients with coronary artery disease

Background: The aortic stiffness is the strongest cardiovascular predictor of morbidity & mortality; it is widely established that cardiovascular hazard factors cause alterations in the histology and function of the aorta. Aim: This research set out to assess the frequency with which Aortic propagation velocity (APV) was seen in coronary artery disease patients (CAD). Methods: This comparative cross-sectional research was conducted at Mansoura specialized hospital from January 2022 to June 2022. One hundred participants participated in this study. The cases were recommended for optional coronary angiography and separated into a CAD group (n= 57) and a non-CAD group (n= 43). Results: Aortic strain (%) 6.10 ± 1.430 versus 11.77 ± 2.809, P < 0.0001), Aortic distensibility (cm 2dyn−110−3) 2.85 ± 0.684 versus 5.35 ± 1.312, P < 0.0001), APV 43.74 ± 10.719 versus 80.18 ± 21.095, P < 0.0001) respectively. APV is a major indicator of the occurrence of CAD (P ˂ 0.001). There is statistically significant negative correlation among APV and SYNTAX score (r = -0.657; P ˂ 0.001). APV is a highly significant predictor of CAD with high sensitivity (82.5%), specificity (97.7%), PPV (97.9%), NPV (80.8%), accuracy (89.0%), and Youden's J index (0.802). The AUC of 0.958 with a 95% CI of 0.925-0.990 (P < 0.001). Conclusion: Coronary artery disease is substantially predicted by the velocity of aortic propagation.