Population
Isolated segments of rabbit abdominal aorta from rabbits with dietary-induced hypercholesterolaemia and…
Comparison
Dietary-induced hypercholesterolaemia vs Age-matched controls on normal diet
Design
Preclinical
Follow-up
8 weeks
Authors
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May indicate sequential endothelial impairment in hypercholesterolemia; leaves open distinct flow- versus agonist-mediated mechanisms for human studies.
Hypercholesterolaemia impairs flow-related EDRF release earlier than acetylcholine-induced relaxation in rabbit aorta, suggesting different transduction mechanisms mediate EDRF release in response to agonists and flow.
Hutcheson et al. (1994) studied this question.
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