Key result
Elevated baseline levels of C-reactive protein were significantly associated with the occurrence of postoperative atrial fibrillation following cardiac surgery (SMD 0.457, p < 0.001).
Why the study?
Are baseline and postoperative levels of CRP and interleukins associated with postoperative atrial fibrillation in patients undergoing cardiac surgery?
Meta-Analysis (n=8,398)
Are baseline and postoperative levels of CRP and interleukins associated with postoperative atrial fibrillation in patients undergoing cardiac surgery?
Standardized Mean Difference: 0.457 (95% CI 0.405–0.509)
Absolute Event Rate: 13.16% vs 10.46%
p-value: p=<0.001
Perioperative assessment of inflammatory markers including CRP, IL-6, IL-8, and IL-10 can help predict and monitor for postoperative atrial fibrillation following cardiac surgery.
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May aid postoperative AF risk stratification via baseline CRP; confirms inflammatory marker associations in cardiac surgery meta-analysis.
Weymann et al. (2018) conducted a meta-analysis in Postoperative atrial fibrillation (n=8,398). Elevated baseline C-reactive protein (CRP) vs. Postoperative sinus rhythm (lower baseline CRP) was evaluated on Association of baseline levels of CRP with the occurrence of postoperative atrial fibrillation (SMD 0.457, 95% CI 0.405-0.509, p=<0.001). Elevated baseline levels of C-reactive protein were significantly associated with the occurrence of postoperative atrial fibrillation following cardiac surgery (SMD 0.457, p < 0.001).
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