Key result
A 12-week weight-reducing dietary intervention in overweight and obese individuals increased subcutaneous adipose tissue HSD11B1 expression by 41% and GRα expression by 34%.
Why the study?
Does weight loss or insulin/FFA infusion alter subcutaneous adipose tissue expression of glucocorticoid-related genes in obese individuals?
Does weight loss or insulin/FFA infusion alter subcutaneous adipose tissue expression of glucocorticoid-related genes in obese individuals?
Glucocorticoid action in subcutaneous adipose tissue is likely an adaptation to metabolic conditions rather than the primary cause of insulin resistance, as weight loss increases HSD11B1 and GRα expression.
Dietary weight loss may alter SAT glucocorticoid gene expression in obesity; leaves open clinical relevance pending larger trials.
baseline C. The effect of weight-reducing dietary intervention on SAT HSD11B1, HSD11B2 and GR expression in overweight/obese individuals in study group 2 (n=38) * P<0.05 vs baseline Data are presented as geometric mean (geometric SD factor)
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Strączkowski et al. (2023) conducted a letter in Obesity and insulin resistance (n=139). Weight-reducing dietary intervention vs. Baseline (pre-intervention) was evaluated on Change in subcutaneous adipose tissue HSD11B1 expression (41% increase, p=<0.001). A 12-week weight-reducing dietary intervention in overweight and obese individuals increased subcutaneous adipose tissue HSD11B1 expression by 41% and GRα expression by 34%.
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