Key result
Subcutaneous adipose tissue 11βHSD1 expression was negatively associated with insulin sensitivity (stβ -0.58, P=0.03) and disposition index in obese African Americans, but not in Hispanics.
Cross-Sectional (n=36)
Subcutaneous adipose tissue 11βHSD1 expression is associated with reduced insulin sensitivity and disposition index in obese African Americans, but not Hispanics, potentially mediated by hepatic fat fraction.
Ethnic differences limit generalizability; hypothesis-generating for targeted 11βHSD1 studies in obese African Americans.
OBJECTIVE: This study examined the contribution of subcutaneous adipose tissue (SAT) 11βHSD1 to obese African Americans' (AA) elevated metabolic risk, despite a protective obesity phenotype of reduced visceral adipose tissue (VAT) and hepatic fat fraction (HFF) relative to obese Hispanics with similar metabolic risk. DESIGN AND METHODS: Obese AA and Hispanic adults (N = 36(16AA); BMI 35.2 ± 0.6 kg/m(2) , 18-25y) participated, with VAT, SAT, and HFF measured by MRI, SAT gene expression measured by HT-12 microarray and insulin sensitivity (SI), disposition index (DI) by IVGTT. Multiple linear regression examined relationships/interactions of ethnicity and 11βHSD1 expression on outcomes (covariates: age, sex, total fat mass), with standardized β (stβ) reported. RESULTS: SAT 11βHSD1 expression significantly associated with insulin parameters and this varied by ethnicity (Pinteraction <0.1). In AA, 11βHSD1 negatively associated with SI (stβ = -0.58, P = 0.03), DI (stβ = -0.62, P = 0.03) and positively associated with fasting insulin (stβ = 0.54, P = 0.04), with no significant relationship in Hispanics. SAT 11βHSD1 associated with HFF in the combined sample (stβ = 0.42, P = 0.008), with no difference between ethnicites (Pinteraction >0.1). After controlling for HFF, 11βHSD1 associations with metabolic risk in AA became nonsignificant. CONCLUSIONS: These results suggested that in AA and not Hispanics, SAT 11βHSD1 is associated with SI and DI, and may be mediated by HFF.
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Gyllenhammer et al. (2013) conducted a cross-sectional in Obesity (n=36). Subcutaneous adipose tissue 11βHSD1 gene expression was evaluated on Insulin sensitivity (SI) (stβ -0.58, p=0.03). Subcutaneous adipose tissue 11βHSD1 expression was negatively associated with insulin sensitivity (stβ -0.58, P=0.03) and disposition index in obese African Americans, but not in Hispanics.
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