Insulin Sensitivity, Insulin Secretion, and Abdominal Fat
Why the study?
How do visceral and subcutaneous abdominal fat depots relate to insulin sensitivity and insulin secretion?
Population
1,457 men and women from the Insulin Resistance Atherosclerosis Study Family Study, mean age 41 years, mean…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Abdominal fat depots may contribute to insulin resistance; cross-sectional data leave causal roles and practice implications open.
Structured PICO
How do visceral and subcutaneous abdominal fat depots relate to insulin sensitivity and insulin secretion?
P
Population
1,457 men and women (999 Hispanic and 458 African-American) from the Insulin Resistance Atherosclerosis Study (IRAS) Family Study, mean age 41 years, mean BMI 28.5 kg/m2.
O
Outcome
Relationship between glucose homeostasis measures (insulin sensitivity [SI], acute insulin response [AIR], and disposition index [DI]) and abdominal fat measures (visceral abdominal tissue [VAT] and subcutaneous abdominal tissue [SAT]).surrogate
Both visceral and subcutaneous abdominal fat depots are important determinants of insulin resistance and insulin secretion.
Cite This Study
Wagenknecht et al. (2003) studied this question.