Key result
Higher visceral fat linked to ~40% greater HOMA-IR per SD in women.
Why the study?
Are abdominal subcutaneous and visceral fat differentially associated with insulin resistance and secretion in men and women?
Population
2253 participants (53% women) from the Netherlands Epidemiology of Obesity study
Design
Cross-sectional
Authors
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May inform sex-specific metabolic risk stratification; leaves open causal mechanisms and targeted interventions.
Cross-Sectional (n=2,253)
Are abdominal subcutaneous and visceral fat differentially associated with insulin resistance and secretion in men and women?
Effect estimate: 40% higher per SD of VAT in women (95% CI 29-52)
Visceral adipose tissue is more strongly associated with insulin resistance in women than in men, highlighting sex differences in the metabolic effects of fat distribution.
Mutsert et al. (2018) conducted a cross-sectional in Insulin resistance and obesity (n=2,253). Abdominal subcutaneous and visceral adipose tissue was evaluated on Homeostatic model assessment of insulin resistance (HOMA-IR) (40% higher per SD of VAT in women, 95% CI 29-52). In women, each standard deviation increase in visceral adipose tissue was associated with a 40% (95% CI 29-52) higher HOMA-IR, whereas in men, visceral and subcutaneous fat had similar associations.
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