Relation of Abdominal Fat Depots to Systemic Markers of Inflammation in Type 2 Diabetes
Why the study?
Are visceral and subcutaneous adipose tissue depots associated with systemic markers of inflammation in patients with type 2 diabetes?
Population
382 subjects with type 2 diabetes from the CHICAGO study cohort
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
VAT may add value beyond BMI for vascular marker assessment in T2D; hypothesis-generating for depot-specific effects pending prospective data.
Structured PICO
Are visceral and subcutaneous adipose tissue depots associated with systemic markers of inflammation in patients with type 2 diabetes?
P
Population
382 subjects with type 2 diabetes from the CHICAGO (Carotid Intima-Media Thickness in Atherosclerosis Using Pioglitazone) study cohort
I
Intervention
Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and BMI
O
Outcome
Systemic inflammatory markers (CRP, MCP, ICAM-1, PAI-1, IL-6, VCAM)surrogate
In patients with type 2 diabetes, visceral adipose tissue provides additional information beyond BMI regarding inflammatory markers related to vascular wall remodeling and coagulation.
Cite This Study
Sam et al. (2009) studied this question.