Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue With Lipoprotein Particle Number and Size in Type 2 Diabetes
Key result
Higher VAT in T2D is linked to increased VLDL and LDL particles and smaller HDL.
- P<0.0001
- n=382
Why the study?
The role of visceral and subcutaneous fat depots, independent of BMI, on the dyslipidemia associated with type 2 diabetes was unclear.
Is visceral adipose tissue associated with atherogenic lipoprotein particle number and size in patients with type 2 diabetes?
Population
382 subjects with type 2 diabetes
Comparison
Visceral adipose tissue vs subcutaneous adipose tissue and BMI
Design
Cross-sectional study with multivariable regression analysis
Authors
Discussion
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Member takes
Implication
VAT links to atherogenic dyslipidemia beyond BMI in T2D; hypothesis-generating for visceral fat targeting, needs prospective trials before practice change.
Study Design
Type
Cross-Sectional (n=382)
Structured PICO
Is visceral adipose tissue associated with atherogenic lipoprotein particle number and size in patients with type 2 diabetes?
P
Population
382 subjects with type 2 diabetes who underwent abdominal computed tomography and fasting blood tests for lipoprotein particle analysis.
E
Exposure
Abdominal computed tomography evaluation of subcutaneous (SAT) and visceral adipose tissue (VAT) distribution
O
Outcome
Lipoprotein particle number and size (VLDL, LDL, HDL) measured using nuclear magnetic resonance spectroscopysurrogate
Main Result
p-value: p=<0.0001
In patients with type 2 diabetes, higher visceral adipose tissue is independently associated with an atherogenic lipoprotein profile, which may increase the risk for atherosclerosis and cardiovascular disease.
Cite This Study
Sam et al. (2008) conducted a cross-sectional in Type 2 diabetes (n=382). Visceral and subcutaneous adipose tissue was evaluated on Lipoprotein particle number and size (p=<0.0001). Higher visceral adipose tissue in type 2 diabetes was independently associated with higher VLDL and LDL particle number, larger VLDL particles, and smaller LDL and HDL particles (P<0.0001).