Key result
T2D is linked to lower pancreas volume and a unique inverse correlation with visceral fat.
Why the study?
The relationship between regional body fat distribution, insulin resistance, and pancreas volume in type-2 diabetes patients was not well characterized.
Does regional body fat distribution correlate with insulin resistance and pancreas volume in patients with type-2 diabetes?
Case-Control (n=104)
Does regional body fat distribution correlate with insulin resistance and pancreas volume in patients with type-2 diabetes?
The ratio of visceral to subcutaneous adipose tissue may help explain the pathogenesis of obesity-related disorders and insulin resistance in type-2 diabetes.
VAT/SAT associations with lower pancreas volume in type 2 diabetes may inform pathogenesis; hypothesis-generating and should not yet change practice.
PURPOSE: We aimed to assess the relationship between the regional body fat distribution and insulin resistance and pancreas volume (PV) in type-2 diabetes (DM) patients. METHODS: Fifty-three consecutive type-2 diabetic and 51 non-diabetic patients matched by age, gender and body mass index (BMI) were enrolled. Subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), waist circumference, and PV were measured with computed tomography. Insulin resistance was assessed by the homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Patients with type-2 DM had significantly lower PV than non-diabetic individuals. HOMA-IR ranged from 0.74 to 6.24; and from 0.37 to 3.26, in type-2 DM patients and non-diabetics, respectively. VAT was positively correlated with HOMA-IR in two groups. There were inverse correlations between PV and VAT and VAT/SAT but only in diabetics. CONCLUSIONS: The VAT/SAT ratio may reflect the possible role of VAT to better understand the pathogenesis of obesity-related disorders in patients with type-2 DM.
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İ. Attila Öz (2017) conducted a case-control in Type-2 diabetes (n=104). Type-2 diabetes vs. Non-diabetic controls was evaluated on Pancreas volume and its correlation with visceral adipose tissue and insulin resistance. Type-2 diabetes was associated with significantly lower pancreas volume compared to non-diabetics, and pancreas volume inversely correlated with visceral adipose tissue only in diabetic patients.
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