Key result
Type 2 diabetes patients exhibit higher liver and pancreas fat fractions regardless of BMI.
Why the study?
Increased obesity causes ectopic fat deposits in the liver and pancreas that affect insulin resistance and blood sugar in type 2 diabetes, prompting assessment of the relationship between obesity, ectopic fat deposits, and diabetes using MR Dixon.
Does the MR Dixon technique reveal differences in liver and pancreas fat fraction between T2DM patients and healthy controls across different BMI categories?
Cross-Sectional (n=157)
No
Does the MR Dixon technique reveal differences in liver and pancreas fat fraction between T2DM patients and healthy controls across different BMI categories?
Absolute Event Rate: 7.86% vs 4.17%
p-value: p=<0.01
The MR Dixon technique demonstrates that T2DM patients have higher ectopic fat deposition in the liver and pancreas, suggesting that tissue fat content should be monitored regardless of BMI.
T2DM-associated ectopic fat deposition independent of BMI is hypothesis-generating; leaves open whether MR Dixon monitoring improves risk stratification or outcomes.
Background The increased obesity results in ectopic fat deposits in liver and pancreas.Ectopic fat deposits affect insulin resistance and blood sugar content with Type 2 Diabetes.To assess the relationship between obesity and ectopic fat deposits and diabetes,this study used MR Dixon method for the quantification of liver and pancreas fat fraction (FF) in T2DM patients and healthy controls. Methods The FF of liver and pancreas, the maximum diameters of the pancreas, SAT, VAT and TAT were measured for 167 subjects using the MR Dixon data.Four groups were established on the basis of BMI value.For statistics, intra-and inter-group comparison was done by employing Independent Sample t Test. Results ① The average fat content in liver and pancreas, the fat content in pancreas body and tail, and VAT in Group 1 were higher than those in Group 3 (P༜0.05). ② The average fat content in liver and pancreas, the adipose fraction of the pancreas head, and VAT in the Group 2 were higher than those in Group 4 (P༜0.05). ③ The average fat content of liver and pancreas, the adipose content of the body and the tail of the pancreas, the abdominal subcutaneous adipose area (SAT), the visceral adipose tissue area (VAT), and the total abdominal adipose tissue area (TAT) in Group 2 were higher than those in the Group 1 (P༜0.05). ④ The FF of pancreas tail, SAT and TAT in Group 4 were higher than those in Group 3 (P༜0.05). Conclusion The tissue FF,which has a close relationship with T2DM,can be assessed by MR Dixon technique.The results showed that all T2DM patients should pay attention to tissue fat content regardless of BMI values.
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Jieqin et al. (2021) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=157). Type 2 Diabetes Mellitus vs. Healthy volunteers was evaluated on Fat fraction in whole liver (FFWL) in subjects with BMI < 25 (p=<0.01). Type 2 diabetes patients exhibited significantly higher fat fractions in the liver and pancreas compared to healthy controls, regardless of BMI.
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