What is the clinical evidence from this study?

Study design: Cohort. Population: Postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) (n=206). Intervention: Statin therapy prior to CABG vs. No statin therapy prior to CABG. Primary outcome: Postoperative atrial fibrillation (POAF) (OR 0.20, 95% CI 0.08-0.51, p=<0.001).

April 13, 2016Indian Heart JournalOpen Access

Statin therapy in the primary prevention of early atrial fibrillation after coronary artery bypass grafting

Q: What are the key findings of this study?

Statin therapy prior to CABG was associated with a significantly reduced risk of postoperative atrial fibrillation (OR 0.20; 95% CI 0.08-0.51; P<0.001).

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Key result

Statin therapy prior to CABG was associated with a significantly reduced risk of postoperative atrial fibrillation (OR 0.20; 95% CI 0.08-0.51; P<0.001).

Why the study?

Does statin therapy prior to CABG prevent postoperative atrial fibrillation in patients without prior atrial fibrillation?

Study Design

Type

Cohort (n=206)

Structured PICO

Does statin therapy prior to CABG prevent postoperative atrial fibrillation in patients without prior atrial fibrillation?

Population

206 patients (mean age 57.2 years) without prior atrial fibrillation who underwent isolated CABG.

Exposure

Statin therapy prior to CABG (all patients also received statin therapy from the first day after CABG).

Comparator

No statin therapy prior to CABG (all patients received statin therapy from the first day after CABG).

Outcome

Postoperative atrial fibrillation (POAF) in the early postoperative period.hard clinical

Main Result

Odds Ratio: 0.2 (95% CI 0.08–0.51)

p-value: p=<0.001

Preoperative statin therapy significantly reduces the risk of early postoperative atrial fibrillation in patients undergoing isolated CABG.

Implication

Supports preoperative statins to lower POAF after CABG; hypothesis-generating pending randomized confirmation.

Abstract

OBJECTIVE: Assessment of the role of statin therapy in the prevention of postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) in patients without prior atrial fibrillation. METHODS: A retrospective analysis of 206 patients, aged 57.2±7.9 years (mean±SD), who underwent isolated CABG is carried out. All patients are divided into two groups. The first group (nSt-patients) includes the patients who did not receive statin therapy prior to CABG (n=82). The second group (St-patients) includes the patients who received statin therapy prior to CABG (n=124). Both groups received the statin therapy from the first day after CABG. The risk of occurrence of POAF is evaluated using the Cox-regression model. RESULTS: /mL in St-patients (P<0.001). The peak WBC numbers occurred on the day of POAF onset. The Cox-regression analysis shows that only two factors (statin therapy and number of grafts) had significant influence on the POAF onset. Odds ratio of POAF event prediction by statin therapy was 0.20 (95%CI: 0.08-0.51), P<0.001. Each subsequent graft increased the risk of POAF in 2.1 times. CONCLUSION: Statin therapy carried out prior to the CABG is an effective approach to primary prevention of POAF in early postoperative period. Statin therapy after CABG in nSt-patients does not give prophylactic effect observed in St-patients.

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Cite This Study

Bockeria et al. (2016) conducted a cohort in Postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) (n=206). Statin therapy prior to CABG vs. No statin therapy prior to CABG was evaluated on Postoperative atrial fibrillation (POAF) (OR 0.20, 95% CI 0.08-0.51, p=<0.001). Statin therapy prior to CABG was associated with a significantly reduced risk of postoperative atrial fibrillation (OR 0.20; 95% CI 0.08-0.51; P<0.001).

synapsesocial.com/papers/6a859dde9df929a58fada546 https://doi.org/10.1016/j.ihj.2016.04.002