Key result
Oral vitamin C significantly reduced the incidence of postoperative atrial fibrillation compared to control (8% vs. 32%, p=0.003) in patients undergoing elective isolated on-pump CABG surgery.
Why the study?
Does oral vitamin C reduce the incidence of postoperative atrial fibrillation in patients undergoing elective isolated on-pump CABG surgery?
RCT (n=100)
randomized
Does oral vitamin C reduce the incidence of postoperative atrial fibrillation in patients undergoing elective isolated on-pump CABG surgery?
Odds Ratio: 8.068 (95% CI 1.783–36.517)
Absolute Event Rate: 8% vs 32%
p-value: p=0.003
Oral vitamin C significantly reduces the incidence of postoperative atrial fibrillation and shortens ICU and hospital stays in patients undergoing elective isolated on-pump CABG surgery.
Supports prophylactic oral vitamin C in elective on-pump CABG; strengthens randomized evidence for postoperative atrial fibrillation prevention.
BACKGROUND: Some evidences have shown the role of antioxidant vitamins in preventing atrial fibrillation (AF) after coronary artery bypass grafting (CABG) surgery. We sought to determine the effect of oral vitamin C on the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery. METHODS: One-hundred patients who underwent isolated CABG surgery were prospectively assigned into two groups: Group 1 - 50 patients received 2 g of oral vitamin C before and 500 mg twice daily lasting for 5 days after surgery; Group 2 - 50 patients as the control group did not receive any. All patients were continuously monitored after surgery in the intensive careunit (ICU), and then Holter monitoring was implemented for 72 h. RESULTS: The mean of patients' age was 61.31 ± 6.42 years. Postoperative AF occurred in 16 and 4 patients in control and treatment groups, respectively (32% vs. 8%, p = 0.003). The ICU stay was 1.79 ± 0.313 and 2.10 ± 0.61 days for vitamin C and control groups, respectively (p = 0.002). The hospital stay was significantly lower in vitamin C group compared with that of the control group (5.32 ± 0.59 vs. 5.74 ± 1.30 days, respectively, p = 0.041). Baseline erythrocyte sedimentation rate (OR 1.030, 95% CI 1.003-1.058, p = 0.030) and taking vitamin C (OR 8.068, 95% CI 1.783-36.517, p = 0.007) were the independent predictors of postoperative AF. CONCLUSIONS: Oral vitamin C can be safely used to decrease the incidence of postoperative AF in patients undergoing elective isolated on-pump CABG surgery.
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Dehghani et al. (2013) conducted an RCT in postoperative atrial fibrillation (n=100). oral vitamin C vs. no vitamin C (control) was evaluated on incidence of postoperative atrial fibrillation (OR 8.068, 95% CI 1.783-36.517, p=0.003). Oral vitamin C significantly reduced the incidence of postoperative atrial fibrillation compared to control (8% vs. 32%, p=0.003) in patients undergoing elective isolated on-pump CABG surgery.
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