Key result
This is a protocol for a systematic review aiming to evaluate pharmacological and non-pharmacological interventions for new-onset atrial fibrillation in adult critically ill patients.
Why the study?
It is unknown whether pharmacological and non-pharmacological interventions for new-onset atrial fibrillation improve patient-important outcomes compared with placebo or no active intervention in adult critically ill patients.
Do pharmacological and non-pharmacological interventions improve mortality, adverse events, and health-related quality of life compared with placebo or no active intervention in adult critically ill patients with new-onset atrial fibrillation?
Systematic Review
Do pharmacological and non-pharmacological interventions improve mortality, adverse events, and health-related quality of life compared with placebo or no active intervention in adult critically ill patients with new-onset atrial fibrillation?
This is a protocol for a systematic review aiming to evaluate the efficacy and safety of interventions for new-onset atrial fibrillation in critically ill adults.
No practice change for new-onset AF in ICU; protocol leaves optimal interventions open pending systematic synthesis.
BACKGROUND: New-onset atrial fibrillation is frequent in critically ill patients and associated with poorer outcomes in these patients. Numerous interventions are used for the management of new-onset atrial fibrillation, but it is unknown if these interventions improve patient-important outcomes as compared with placebo or no active intervention in adult critically ill patients. METHODS/DESIGN: We will conduct a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials assessing pharmacological and non-pharmacological interventions of new-onset atrial fibrillation as compared with placebo or no active intervention in adult critically ill patients. The primary outcomes are mortality, adverse events and health-related quality of life. We will search the following databases: MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, Science Citation Index and BIOSIS and follow the recommendations by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We will evaluate the overall certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. DISCUSSION: New-onset atrial fibrillation is common in adult critically ill patients. However, the balance between the desirable and undesirable effects of pharmacological and non-pharmacological interventions is unknown. The outlined systematic review aims to provide updated data on this topic. REGISTRATION: Submitted to PROSPERO (CRD42020187178 ). Status: accepted.
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Wetterslev et al. (2020) conducted a systematic review in New-onset atrial fibrillation in critically ill patients. Pharmacological and non-pharmacological interventions vs. Placebo or no active intervention was evaluated on Mortality, adverse events and health-related quality of life. This is a protocol for a systematic review aiming to evaluate pharmacological and non-pharmacological interventions for new-onset atrial fibrillation in adult critically ill patients.
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