Answers are grounded in this paper and cite their sources.
The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(V) fluoride adducts has been investigated. The results show that the IMe-PF5 derivative (IMe = 1,3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted 18F–19F isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo.
No takes yet. Share an insight, caveat, or question.
Vabre et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: