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A component (protein ARC) antigenically related to the uncommon amyloid fibril protein AR was detected in 16 of 352 sera with M‐components. Another serum component (protein ASC), related to the commoner nonimmunoglobulin amyloid fibril subunit protein AS. was found in 149 of the same 352 sera. However, only one of the 16 sera with protein ARC contained protein ASC. giving evidence for a high degree of mutual exclusion between the two amyloid fibril‐related components in serum. A considerable deviation of the normal χ/δ ratio towards a predominance of the δ type of light chain was seen among the sera with monoclonal IgG or IgA and protein ARC. No similar deviation of the χ/δ ratio could be observed among the sera with protein ASC.
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Husby et al. (1974) studied this question.
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