Key result
Novel renal biomarkers including cystatin C, NGAL, and interleukin-18 offer improved early prognostic stratification in acute coronary syndrome compared to classic markers like creatinine and urea.
Novel renal biomarkers such as cystatin C, NGAL, and IL-18 offer added value for early prognostic stratification in patients with acute coronary syndrome.
Mezi ledvinami a srdcem probĂhĂĄ tÄsnĂĄ patofyziologickĂĄ interakce, kterĂĄ mimo jinĂŠ ovlivĹuje riziko vzniku i prognĂłzu mnoha kardiovaskulĂĄrnĂch onemocnÄnĂ. ÄasnĂĄ rizikovĂĄ stratifikace pacientĹŻ s akutnĂm koronĂĄrnĂm syndromem (AKS) je dĹŻleĹžitĂĄ pro optimalizaci terapie. V pĹedloĹženĂŠm pĹehledu jsou uvedeny moĹžnosti prognostickĂŠ stratifikace pacientĹŻ s AKS na zĂĄkladÄ vstupnĂch koncentracĂ biomarkerĹŻ renĂĄlnĂch funkcĂ. ZmĂnÄny jsou klasickĂŠ biomarkery (kreatinin, urea), kterĂŠ majĂ dominantnĂ vĂ˝znam spĂĹĄe jiĹž u rozvinutĂŠho chronickĂŠho onemocnÄnĂ ledvin, a takĂŠ nÄkterĂŠ novÄjĹĄĂ biomarkery (cystatin C, NGAL, interleukin 18), kterĂŠ pĹinĂĄĹĄejĂ pĹidanou hodnotu dĂky pĹesahu tÄchto biomarkerĹŻ pĹĂmo do patofyziologickĂ˝ch mechanismĹŻ prĹŻbÄhu AKS.
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Přeček et al. (2017) conducted a review in Acute coronary syndrome. Renal function biomarkers (creatinine, urea, cystatin C, NGAL, IL-18) was evaluated. Novel renal biomarkers including cystatin C, NGAL, and interleukin-18 offer improved early prognostic stratification in acute coronary syndrome compared to classic markers like creatinine and urea.
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