Key result
Fasting plasma HDL cholesterol was increased by 57% in LIPG knockout mice and decreased by 19% in human LIPG transgenic mice compared with syngeneic controls.
Why the study?
Does genetic modulation of endothelial lipase expression alter HDL cholesterol levels in mice?
Does genetic modulation of endothelial lipase expression alter HDL cholesterol levels in mice?
Effect estimate: 57% increase
Absolute Event Rate: 119.2% vs 76%
p-value: p=<0.001
Endothelial lipase is a major physiological determinant of HDL cholesterol levels in vivo, with its expression inversely correlating with HDL levels.
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Endothelial lipase modulation alters HDL in mice; leaves open therapeutic targeting in human dyslipidemia.
Ishida et al. (2003) studied HDL metabolism. Endothelial lipase gene (LIPG) knockout vs. Wild-type syngeneic control mice was evaluated on Fasting plasma HDL cholesterol level (57% increase, p=<0.001). Fasting plasma HDL cholesterol was increased by 57% in LIPG knockout mice and decreased by 19% in human LIPG transgenic mice compared with syngeneic controls.
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