Population
Wild-type (WT) and mutant heparan sulfate proteoglycan-deficient Chinese hamster ovary cells (745 cells)
Comparison
Transfection with pCMV5-apoB17-DAF plasmid to… vs Non-transfected WT and 745 cells
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether apoB N-terminal fragments modulate LPL in vivo or human dyslipidemia.
Cell-surface expression of the amino-terminal fragment of apolipoprotein B increases the amount and affinity of lipoprotein lipase binding to cells.
Pang et al. (1996) studied this question.
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