Why the study?
Does decreased Angptl3 expression reduce hyperlipidemia and atherosclerosis in apoE-deficient mice?
Population
Apolipoprotein E knockout (apoEKO) mice
Comparison
Recessive mutation of the angiopoietin-like 3… vs ApoEKO mice without the hypl mutation
Design
Preclinical
Authors
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May support Angptl3 as a lipid target in hyperlipidemia models; leaves open translation to human atherosclerosis prevention.
Does decreased Angptl3 expression reduce hyperlipidemia and atherosclerosis in apoE-deficient mice?
Decreased Angptl3 expression protects against hyperlipidemia and atherosclerosis in apoE-deficient mice by enhancing the catabolism and clearance of TG-rich lipoproteins.
Shimizugawa et al. (2003) studied this question.
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