What question did this study set out to answer?

Investigate whether phosphorus-31 nuclear magnetic resonance spectroscopy can noninvasively detect the characteristic metabolic defects in a suspected case of McArdle syndrome.

May 28, 1981New England Journal of Medicine

Examination of a Case of Suspected McArdle's Syndrome by31P Nuclear Magnetic Resonance

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Authors

BRBrian D. RossDartmouth College GRGeorge K. RaddaScience Oxford DGDavid G. GadianGreat Ormond Street Hospital

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Implication

Case report reveals noninvasive metabolic evaluation using phosphorus-31 magnetic resonance in suspected McArdle syndrome, suggesting an effective diagnostic alternative to open muscle biopsy.

Key Points

Investigate whether phosphorus-31 nuclear magnetic resonance spectroscopy can noninvasively detect the characteristic metabolic defects in a suspected case of McArdle syndrome.
Examined a patient with exercise intolerance and suspected glycogen phosphorylase deficiency.
Conducted phosphorus-31 nuclear magnetic resonance (31P-NMR) spectroscopy to noninvasively observe cellular energetics and metabolic changes in skeletal muscle during exercise.
Evaluated findings relative to conventional diagnostic standards, including ischemic forearm testing and muscle biopsy.
Demonstrated an absence of intracellular acidification during muscle contraction, reflecting failure of anaerobic glycogenolysis.
Characterized impaired muscle high-energy phosphate metabolism noninvasively, providing diagnostic confirmation without initial reliance on surgical tissue sampling.

Cite This Study

Ross et al. (1981) studied this question.

synapsesocial.com/papers/6a85a61c581d4f62e2d5b206 https://doi.org/10.1056/nejm198105283042206

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Implication

Case report reveals noninvasive metabolic evaluation using phosphorus-31 magnetic resonance in suspected McArdle syndrome, suggesting an effective diagnostic alternative to open muscle biopsy.

Examination of a Case of Suspected McArdle's Syndrome by31P Nuclear Magnetic Resonance

Discussion

Member takes

Implication

Key Points

Cite This Study

Examination of a Case of Suspected McArdle's Syndrome by31P Nuclear Magnetic Resonance

Discussion

Member takes

Implication

Key Points

Cite This Study

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