Why the study?
Does hepatitis A vaccination prime the immune system in initially seropositive infants despite maternal antibody interference?
Population
397 infants (297 enrolled at age 6 to 10 weeks, 100 enrolled at 12 months of age)
Comparison
Hepatitis A vaccine at 2, 4 and 6 months… vs Comparison between initially seropositive…
Design
Cohort
Follow-up
Up to 13 months of age
Authors
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Supports HepA priming despite maternal antibodies in infants; hypothesis-generating before schedule changes.
Does hepatitis A vaccination prime the immune system in initially seropositive infants despite maternal antibody interference?
Hepatitis A vaccination in the first year of life successfully primes the immune system in infants even in the presence of maternal antibodies.
Dagan et al. (2000) studied this question.
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