Key result
Oral sildenafil decreased pulmonary arterial pressure in 82.4% (28 of 34) of monitored pediatric patients with persistent pulmonary hypertension following congenital heart surgery.
Why the study?
Does oral sildenafil improve pulmonary arterial pressure in paediatric patients with persistent pulmonary hypertension early after congenital cardiac surgery?
Population
100 paediatric patients with persistent pulmonary hypertension early after congenital cardiac surgery.
Design
Cohort
Follow-up
Early post-operative period (ICU stay)
Authors
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May support consideration of oral sildenafil in this setting; leaves open confirmation via randomized trials.
Observational (n=100)
Does oral sildenafil improve pulmonary arterial pressure in paediatric patients with persistent pulmonary hypertension early after congenital cardiac surgery?
Oral sildenafil appears to be a safe and effective alternative for managing persistent pulmonary hypertension following congenital heart surgery in children.
Nemoto et al. (2010) conducted an observational in Persistent pulmonary hypertension early after congenital cardiac surgery (n=100). Oral sildenafil was evaluated on Decrease in pulmonary arterial pressure. Oral sildenafil decreased pulmonary arterial pressure in 82.4% (28 of 34) of monitored pediatric patients with persistent pulmonary hypertension following congenital heart surgery.
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