January 1, 1984Folia Endocrinologica JaponicaOpen Access

Serum Angiotensin I Converting Enzyme Activity in Patients with Hyperthyroidism and Hypothyroidism : Relation to Renin and Aldosterone

View Full Paper

Ask AI

Bookmark

Why the study?

Does thyroid status affect serum ACE activity and its relationship with the renin-angiotensin-aldosterone system?

Population

88 subjects including 30 patients with hyperthyroidism, 7 patients with hypothyroidism, and 51 normal…

Comparison

Furosemide and upright posture in a subset of… vs Normal subjects and hypothyroid patients.

Design

Cross-sectional

Authors

MGMitsuhiro GOTOHImperial Household Agency KMKenji MizunoTottori University Hospital JMJunichiroh MATSUISendai Kousei Hospital

Discussion

Member takes

Implication

Elevated ACE in hyperthyroidism should not yet change practice; leaves open whether thyroid status modulates RAAS inhibitor response.

Structured PICO

Does thyroid status affect serum ACE activity and its relationship with the renin-angiotensin-aldosterone system?

Population

88 subjects including 30 patients with hyperthyroidism (mean age 38.6, 12 male), 7 patients with hypothyroidism (mean age 52.6, 2 male), and 51 normal subjects (mean age 37.2, 28 male).

Intervention

Furosemide (1 mg/kg i.v.) and upright posture (2h) in a subset of patients (23 hyperthyroid, 6 hypothyroid, 10 normal) to stimulate renin secretion.

Comparator

Normal subjects and hypothyroid patients.

Outcome

Serum angiotensin I converting enzyme (ACE) activity, plasma renin activity (PRA), and plasma aldosterone concentration (PAC).surrogate

Serum ACE activity is elevated in hyperthyroidism and correlates with plasma renin activity and aldosterone, suggesting it is modulated by the renin-angiotensin system rather than directly by thyroid hormones.

Cite This Study

GOTOH et al. (1984) studied this question.

synapsesocial.com/papers/6a85aa4f57a6378aebd0c217 https://doi.org/10.1507/endocrine1927.60.7_835

View Full Paper

Ask AI

Bookmark

Serum Angiotensin I Converting Enzyme Activity in Patients with Hyperthyroidism and Hypothyroidism : Relation to Renin and Aldosterone

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Serum Angiotensin I Converting Enzyme Activity in Patients with Hyperthyroidism and Hypothyroidism : Relation to Renin and Aldosterone

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider