Key result
4D optical coherence tomography and high-speed video microscopy successfully visualized the dynamic behavior and structural differences between healthy and calcified murine aortic valves ex vivo.
4D optical coherence tomography is a feasible imaging technique for ex vivo visualization and quantification of aortic valve dynamics in murine models of calcific aortic valve disease.
Supports 4D OCT feasibility in murine valve models; leaves open translation to human calcific aortic valve disease assessment.
The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain and undergo fatigue, which impinge upon cardiac output. The knowledge about changes of the dynamic behavior and the possibility of early stage diagnosis could lead to the development of new treatment strategies. Animal models are suited for the development and evaluation of new experimental approaches and therefor innovative imaging techniques are necessary. In this study, we present the time resolved visualization of healthy and calcified aortic valves in an ex vivo artificially stimulated heart model with 4D optical coherence tomography and high-speed video microscopy.
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Schnabel et al. (2014) studied Calcific aortic valve stenosis (n=17). 4D optical coherence tomography and high-speed video microscopy was evaluated on Feasibility of time-resolved visualization of healthy and calcified aortic valves. 4D optical coherence tomography and high-speed video microscopy successfully visualized the dynamic behavior and structural differences between healthy and calcified murine aortic valves ex vivo.
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