Key result
The DOCK7 rs1748195 SNP was associated with an increased risk of coronary artery disease (OR 1.27), whereas the ANGPTL3 rs12563308 SNP was associated with a decreased risk (OR 0.73).
Why the study?
Do DOCK7 rs1748195 and ANGPTL3 rs12563308 SNPs and their haplotypes affect serum lipid levels and the risk of CAD and IS in a Southern Chinese Han population?
Case-Control (n=1,728)
No
Do DOCK7 rs1748195 and ANGPTL3 rs12563308 SNPs and their haplotypes affect serum lipid levels and the risk of CAD and IS in a Southern Chinese Han population?
Odds Ratio: 1.27 (95% CI 1.02–1.57)
p-value: p=0.014
DOCK7 rs1748195 and ANGPTL3 rs12563308 SNPs and their haplotypes are significantly associated with the risk of CAD and the angiographic severity of coronary atherosclerosis in a Southern Chinese Han population.
DOCK7/ANGPTL3 SNPs were associated with CAD risk in this cohort; leaves open replication, lipid effects, and clinical utility.
BACKGROUND: Little is known about the association of the dedicator of cytokinesis 7 (DOCK7 rs1748195) and angiopoietin like 3 (ANGPTL3 rs12563308) single nucleotide polymorphisms (SNPs) and their haplotypes with serum lipid levels and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Chinese populations. This study aimed to detect such association in a Southern Chinese Han population. METHODS: This study included 1728 subjects (CAD, 568; IS, 539; and controls, 621). Genotypes of the two SNPs were determined by the Snapshot technology. RESULTS: The genotypic and allelic frequencies of the rs1748195 SNP were different between CAD patients and controls (P < 0.05 for each), the rs1748195G allele frequency was higher in CAD patients than in controls (27.6% vs. 23.6%, P = 0.024). The genotypic frequencies of the rs12563308 SNP were also different between CAD patients and controls (P = 0.021). The rs1748195 SNP was associated with an increased risk of CAD after controlling for potential confounders and Bonferroni correction (P < 0.025 considered statistically significant; Recessive: OR = 1.79, 95% CI = 1.04-3.06, P = 0.017; Log-additive: OR = 1.27, 95% CI = 1.02-1.57, P = 0.014), whereas the rs12563308 SNP was associated with a decreased risk of CAD (Dominant: OR = 0.69, 95% CI = 0.45-0.94, P = 0.011; Log-additive: OR = 0.73, 95% CI = 0.49-0.89, P = 0.009). The rs1748195 SNP was also associated with an increased risk of severity to coronary artery atherosclerosis (Dominant: OR = 1.45, 95% CI = 1.07-2.11, P = 0.017; Log-additive: OR = 1.35, 95% CI = 1.09-1.82, P = 0.013). The interactions of SNP-environment on serum lipid levels and the risk of severity to coronary artery atherosclerosis, CAD and IS were noted. The rs1748195G-rs12563308T haplotype was associated with an increased angiographic severity to coronary artery atherosclerosis (OR = 1.46, 95% CI = 1.05-2.03), and the risk of CAD (OR = 1.37, 95% CI = 1.08-1.74). The interactions of haplotype-hypertension on the risk of CAD and haplotype-drinking on the risk of CAD/IS were observed. CONCLUSIONS: These results suggest that the DOCK-ANGPTL3 SNPs and their haplotypes were associated with the angiographic severity to coronary artery atherosclerosis and the risk of CAD and IS in the Southern Chinese Han population.
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Li et al. (2018) conducted a case-control in Coronary artery disease and ischemic stroke (n=1,728). DOCK7 rs1748195 and ANGPTL3 rs12563308 SNPs vs. Non-carriers / wild-type genotypes was evaluated on Risk of coronary artery disease (CAD) (OR 1.27, 95% CI 1.02-1.57, p=0.014). The DOCK7 rs1748195 SNP was associated with an increased risk of coronary artery disease (OR 1.27), whereas the ANGPTL3 rs12563308 SNP was associated with a decreased risk (OR 0.73).
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