Cyclodextrin derivatives for the GC separation of racemic mixtures of volatile compounds. Part VI: The influence of the diluting phase on the enantioselectivity of 2,6‐Di‐O‐methyl‐3‐O‐pentyl‐β‐cyclodextrin

As a continuation of previous studies on the use of cyclodextrin derivatives (CD) for the separation of volatile compounds by capillary GC, the influence of diluting phases other than OV‐1701 or OV‐1701‐OH has been investigated. 2,6‐Di‐ O ‐methyl‐3‐ O ‐pentyl‐β‐cyclodextrin (2,6‐DiMe‐3‐Pe‐β‐CD) was taken as the reference CD derivative, because of the large number of volatile racemates it is able to separate; OV‐1701 or OV‐1701‐OH was chosen as the reference diluting phase. The performance of a column coated with a 0.15 μm film of 10 % 2,6‐DiMe‐3‐Pe‐β‐CD in OV‐1701 was compared with that of analogous columns coated with films of the same thickness containing the same percentage of the CD derivative diluted with stationary phases of different polarity, i.e. PS‐086, PS‐347.5, and OV‐225. Resolution values and separation factors of thirty racemates were used to evaluate the effect of different diluting phases on column performance.