What question did this study set out to answer?

To identify spatial gene expression differences along the aorta and evaluate the role of HOXA4 in the pathogenesis of human abdominal aortic aneurysms.

May 31, 2011BMC PhysiologyOpen Access

Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms

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Authors

JLJohn H. LillvisVA Western New York Healthcare System RERobert ErdmanTiGenix (Spain)CSCharles M. SchworerGeisinger Medical Center

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Implication

Experimental study reveals reduced regional HOXA4 expression in human abdominal aortic aneurysms, suggesting a developmental gene link to aortic disease susceptibility.

Key Points

To identify spatial gene expression differences along the aorta and evaluate the role of HOXA4 in the pathogenesis of human abdominal aortic aneurysms.
Screened spatial aortic gene expression in baboon models using microarrays to detect regional HOX gene variations.
Quantified HOXA4 protein and transcript expression across 24 human aortic specimens, comparing abdominal aortic aneurysms to age-matched non-aneurysmal controls.
Evaluated HOXA4 protein expression in cultured human aortic endothelial and smooth muscle cells following stimulation with interferon-gamma.
HOXA4 protein levels were significantly higher in thoracic versus abdominal aortic tissue (P < 0.001), localizing to the nuclei and perinuclear regions of endothelial and smooth muscle cells.
Human abdominal aortic aneurysm tissues exhibited significant downregulation of HOXA4 transcript levels relative to age-matched controls (P < 0.00004).
Interferon-gamma stimulation of cultured aortic endothelial and smooth muscle cells significantly decreased HOXA4 protein levels (P < 0.0007).

Cite This Study

Lillvis et al. (2011) studied this question.

synapsesocial.com/papers/6a85b4a9c006613b201aefe7 https://doi.org/10.1186/1472-6793-11-9

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Implication

Experimental study reveals reduced regional HOXA4 expression in human abdominal aortic aneurysms, suggesting a developmental gene link to aortic disease susceptibility.

Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms

Discussion

Member takes

Implication

Key Points

Cite This Study

Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms

Discussion

Member takes

Implication

Key Points

Cite This Study

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