Key result
In a 35-year-old woman with ACTH-independent Cushing's syndrome, unknown molecular defects may favor both micronodular adrenal hyperplasia and ectopic adrenocortical adenoma.
Population
35-year-old woman with ACTH-independent hypercortisolism associated with both micronodular adrenal…
Design
Case_report
Authors
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Hypothesis-generating in ACTH-independent Cushing's; leaves open whether unidentified molecular defects drive multifocal adrenal disease.
Case Report (n=1)
This case suggests that unknown molecular defects can favor both micronodular adrenal hyperplasia and ectopic adrenocortical adenoma associated with Cushing's syndrome.
Louiset et al. (2009) conducted a case report in ACTH-independent Cushing's syndrome (n=1). In vivo and in vitro genetic and histological evaluation was evaluated on Detection of 17alpha-hydroxylase and 21-hydroxylase immunoreactivities, quantification of CYP11B1 mRNA, and measurement of cortisol levels. In a 35-year-old woman with ACTH-independent Cushing's syndrome, unknown molecular defects may favor both micronodular adrenal hyperplasia and ectopic adrenocortical adenoma.
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