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Central AT1 blockade selectively inhibits Ang II thirst in rats; extends mechanistic understanding but leaves open human therapeutic implications.
In the rat, intakes of water and 1.8% NaCl induced by I.C.V. angiotensin II were inhibited by prior I.C.V. injection of the angiotensin subtype 1 receptor antagonist, Losartan, but not by the subtype 2 receptor antagonist, CGP 42112B. Drinking induced by I.C.V. carbachol was unaffected by either antagonist.
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Beresford et al. (1992) studied this question.
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