Gene transfer of troponin I chimeras helps define the functional domains responsible for regulating force generation in adult cardiac myocytes.
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Hypothesis-generating for troponin I domain function in myocytes; extends chimeric mapping but leaves open translation to human disease.
Troponin I, a key myofilament protein, plays a critical role in regulating force generation in striated muscle by acting as a Ca 2+ -dependent molecular switch. Domains contributing to the functional properties of troponin I have recently been defined in intact myofilaments of adult cardiac myocytes. This has been attained using gene transfer of chimeras derived from two troponin I isoforms expressed during cardiac development.
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Westfall et al. (2001) studied this question.
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