Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases

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This review examines troponin I's role in muscle contraction and mutations linked to cardiomyopathies, indicating its importance in muscle health.

Troponin I is crucial for regulating muscle contraction and relaxation in striated muscles through calcium interaction.
Mutations in troponin I significantly impact conditions such as hypertrophic and dilated cardiomyopathies.
Posttranslational modifications, especially phosphorylation, play a significant role in troponin I's function and calcium sensitivity.
Understanding troponin I's structure and function helps reveal its implications in muscle diseases and cardiac health.

Han et al. (2025) studied this question.

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This review examines troponin I's role in muscle contraction and mutations linked to cardiomyopathies, indicating its importance in muscle health.