Key result
Phosphorylation of cardiac troponin I by various protein kinases serves as a major physiological mechanism for modulating myofilament properties and cardiac contractile function.
This review highlights the critical role of cardiac troponin I phosphorylation by various kinases in modulating cardiac contractile function and its implications in heart failure.
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cTnI phosphorylation modulates contractility in HF; leaves open kinase-specific targets for prospective therapeutic validation.
Layland et al. (2005) conducted a review in Cardiac contractile dysfunction. Cardiac troponin I (cTnI) phosphorylation was evaluated. Phosphorylation of cardiac troponin I by various protein kinases serves as a major physiological mechanism for modulating myofilament properties and cardiac contractile function.
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