The Relationship between Blood Pepsin Level, ABO Blood Group, and Secretor Status

Article1 April 1962The Relationship between Blood Pepsin Level, ABO Blood Group, and Secretor StatusJAMES C. NIEDERMAN, M.D., EDWARD C. GILBERT, M.D., HOWARD M. SPIRO, M.D.JAMES C. NIEDERMAN, M.D.Search for more papers by this author, EDWARD C. GILBERT, M.D.Search for more papers by this author, HOWARD M. SPIRO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-564 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAssociations between specific diseases and certain hereditary characteristics are becoming increasingly apparent. In particular, the relationship between blood groups and peptic ulcer disease has been amply documented. In 1954, Aird, Bentall, Mehigan, and Fraser Roberts (1) emphasized the increased incidence of blood group O among adult males with duodenal ulcer; further observations revealed that those patients with duodenal ulcer who subsequently required operation accounted to a large extent for this blood group O excess (2). Clinical studies have demonstrated the additional physiologic importance of secretion of mucopolysaccharide ABH substances into body fluids, especially those of the stomach (3). A significantly...References1. AIRDBENTALLMEHIGANFRASER ROBERTS IHHJAJA: Blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast and bronchus. Brit. Med. J. 2: 315, 1954. CrossrefMedlineGoogle Scholar2. PEEBLES BROWNMELROSEWALLACE DAAGJ: The blood groups in peptic ulceration. Brit. Med. J. 2: 135, 1956. CrossrefMedlineGoogle Scholar3. CLARKECOWANWYN EDWARDSHOWEL-EVANSMCCONNELLWOODROWSHEPPARD CAWKJAWRBJCPM: The relationship of the ABO blood groups to duodenal and gastric ulceration. Brit. Med. J. 2: 643, 1955. CrossrefMedlineGoogle Scholar4. CLARKEWYN EDWARDSHADDOCKHOWEL-EVANSMCCONNELLSHEPPARD CAJDRAWRBPM: ABO blood groups and secretor character in duodenal ulcer. Brit. Med. J. 2: 725, 1956. CrossrefMedlineGoogle Scholar5. WALLACEPEEBLES BROWNCOOKMELROSE JDAIAAG: The secretor status in duodenal ulcer. Scot. Med. J. 3: 105, 1958. CrossrefMedlineGoogle Scholar6. MCCONNELL RB: Secretion of blood group antigens in gastrointestinal diseases. Gastroenterologia (Basel) 92: 103, 1959. CrossrefGoogle Scholar7. SPIRORYANJONES HMAECM: The relation of blood pepsin to gastric secretion, with particular reference to anacidity and achylia. Gastroenterology 30: 563, 1956. CrossrefMedlineGoogle Scholar8. SPIRORYANJONES HMAECM: The utility of the blood pepsin assay in clinical medicine. New Engl. J. Med. 253: 261, 1955. CrossrefMedlineGoogle Scholar9. RACESANGER RRR: Blood Groups in Man, 2d ed., Oxford University Press, New York, 1954. Google Scholar10. SIEVERS ML: Hereditary aspects of gastric secretory function. Amer. J. Med. 27: 246, 1959. CrossrefMedlineGoogle Scholar11. VENTZKEGROSSMAN LEML: Response of patients with duodenal ulcer to augmented histamine test as related to blood groups and to secretor status. Clin. Res. 10: 76, 1962. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES C. NIEDERMAN, M.D.; EDWARD C. GILBERT, M.D.; HOWARD M. SPIRO, M.D.Affiliations: New Haven, ConnecticutFrom the Department of Epidemiology and Public Health and the Department of Medicine, Yale University School of Medicine.Supported by United States Public Health Service Grant A2747, and in part by Grants C2578, A3473, and A5100.Requests for reprints should be addressed to James C. Niederman, M.D., Department of Epidemiology and Public Health, Yale University School of Medicine, 333 Cedar Street, New Haven 11, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMultiplicative effect of hyperpepsinogenemia I and non-secretor status on the risk of duodenal ulcer in siblingsDistributions of Genetic Markers in United States Populations: I. Blood Group and Secretor SystemsHereditary aspects of duodenal ulceration: pepsin 1 secretion in relation to ABO blood groups and ABH secretor status.Blood Groups and Alimentary DisordersLong-Term Survival of Patients with Gastrointestinal Haemorrhage with Special Reference to the ABO Blood GroupsABO blood groups and gastrointestinal function.THE BLOOD GROUP POLYMORPHISMS: WHY ARE THEY THERE?**Supported in part, by U.S.A.E.C. grant #AT(11-1) 1552The ABO and Lewis Blood-Group SystemStatistische Beziehungen zwischen den ABO-Blutgruppen und Krankheiten mit Ausnahme der InfektionskrankheitenConstitution, genetics, and body form in peptic ulcer: A reviewEthnic group and serum pepsinogenCauses of peptic ulcerA statistical appraisal on the relationship between non-ABO blood group systems and diseasesBlood-groups and the IntestineABO BLOOD GROUP, SECRETOR STATUS AND GASTRIC SECRETIONABO blood group and secretor status in relation to clinical characteristics of peptic ulcersMedical genetics 1962Associations and linkage in human geneticsPeptic Ulcer 1 April 1962Volume 56, Issue 4Page: 564-569KeywordsBlood groupsDuodenal ulcersGastric ulcersGenetic diseasesMedical servicesPepsinsPeptic ulcersPrevention, policy, and public healthSalivaStomach ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...