Key result
Whole body sodium depletion significantly reduced 5-HT content and increased Agtr1a mRNA expression in the dorsal raphe nucleus, though AT1 receptor blockade did not influence sodium intake.
Why the study?
The study investigated the existence of Ang II AT1 receptors in serotonergic DRN neurones and whether whole body sodium depletion affects AT1a receptor subtype gene expression and functional significance.
Comparison
Whole body sodium depletion and losartan treatment vs controls
Authors
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Sodium depletion alters SFO/DRN 5-HT and Agtr1a signaling in rodents; leaves open DRN AT1 receptor role in salt appetite and warrants further study.
Whole body sodium depletion alters serotonin content and Agtr1a mRNA expression in the dorsal raphe nucleus, though the functional role of AT1 receptors in this region remains unclear.
Porcari et al. (2019) studied Sodium depletion. Whole body sodium depletion and Losartan was evaluated on Agtr1a mRNA expression, 5-HT content, and NaCl intake. Whole body sodium depletion significantly reduced 5-HT content and increased Agtr1a mRNA expression in the dorsal raphe nucleus, though AT1 receptor blockade did not influence sodium intake.
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