Key result
Bilateral laparoscopic adrenalectomy successfully treated endogenous Cushing's syndrome in two patients with rare primary bilateral adrenal nodular diseases, specifically PPNAD and PBMAH.
Case Report (n=2)
No
Highlights the rare presentation of bilateral adrenal nodular disease as a cause of endogenous Cushing's syndrome.
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syndrome; leaves open the long-term cardiometabolic outcomes of surgical management in these specific populations.
Primary adrenal disorders contribute 20%â€"30% of patients with endogenous Cushing's syndrome. Most of the primary adrenal diseases are unilateral and include adenoma and adrenocortical carcinoma, whereas bilateral adrenal lesions are uncommon and include primary pigmented nodular adrenocortical disease, primary bilateral macronodular adrenocortical hyperplasia, isolated micronodular adrenocortical disease, bilateral adenomas or carcinomas, and rarely pituitary adrenocorticotropic hormone-dependent adrenal nodular disease. Cyclic adenosine monophosphate-dependent protein kinase A signalling is the major activator of cortisol secretion in primary adrenal nodular disorders. We report two cases of bilateral adrenal nodular disease with endogenous Cushing's syndrome, including one each of primary pigmented nodular adrenocortical disease and primary bilateral macronodular adrenocortical hyperplasia.
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Jarial et al. (2017) conducted a case report in Primary bilateral adrenal nodular disease with Cushing's syndrome (n=2). Bilateral laparoscopic adrenalectomy was evaluated. Bilateral laparoscopic adrenalectomy successfully treated endogenous Cushing's syndrome in two patients with rare primary bilateral adrenal nodular diseases, specifically PPNAD and PBMAH.
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