Key result
Complete electrolytic lesions of the subfornical organ significantly reduced the pressor effect of intravenous angiotensin II in unrestrained rats.
Why the study?
Do subfornical organ lesions reduce the pressor effect of systemic angiotensin II in unrestrained rats?
Population
unrestrained rats
Comparison
electrolytic lesions of the subfornical organ vs before lesions, partial SFO lesions, or control…
Design
Preclinical
Authors
Loading...
Supports central mediation of angiotensin II pressor effects via subfornical organ in rats; leaves open translation to human hypertension.
Do subfornical organ lesions reduce the pressor effect of systemic angiotensin II in unrestrained rats?
The study demonstrates that a significant portion of the pressor action of circulating angiotensin II is centrally mediated via the subfornical organ.
Mangiapane et al. (2008) studied this question. Electrolytic lesions of the subfornical organ (SFO) vs. Before lesions, partial SFO lesions, or control lesions in adjacent tissue was evaluated on Pressor effect of intravenous angiotensin II. Complete electrolytic lesions of the subfornical organ significantly reduced the pressor effect of intravenous angiotensin II in unrestrained rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: