Key result
Recent exome sequencing and genome-wide association studies have identified rare and common genetic factors associated with a predisposition to spontaneous coronary artery dissection.
Why the study?
The underlying pathophysiological and genetic mechanisms of spontaneous coronary artery dissection remain poorly understood despite recent exploratory sequencing and genome-wide association studies.
This review highlights recent advances in understanding the genetic basis of spontaneous coronary artery dissection, emphasizing the emerging role of exome sequencing and genome-wide association studies.
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Exploratory exome and GWAS leads generate SCAD pathogenesis hypotheses; clinical implications remain undetermined pending validation.
Amrani-Midoun et al. (2021) conducted a review in Spontaneous coronary artery dissection (SCAD). Genetic factors was evaluated. Recent exome sequencing and genome-wide association studies have identified rare and common genetic factors associated with a predisposition to spontaneous coronary artery dissection.
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