Key result
Resveratrol improves vascular function and blood pressure through mechanisms including increased nitric oxide, reduced oxidative stress, and immune modulation.
Resveratrol exhibits protective effects on vascular function and blood pressure through multiple molecular pathways including eNOS upregulation and oxidative stress reduction.
Should not change hypertension management; extends preclinical mechanistic evidence on resveratrol.
Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling. At the same time, resveratrol inhibits the synthesis of endothelin-1 and reduces oxidative stress in both endothelial cells and smooth muscle cells. Pathological stimuli-induced smooth muscle cell proliferation, vascular remodeling, and arterial stiffness can be ameliorated by resveratrol as well. In addition, resveratrol also modulates immune cell function, inhibition of immune cell infiltration into the vascular wall, and improves the function of perivascular adipose tissue. All these mechanisms contribute to the protective effects of resveratrol on vascular function and blood pressure in vivo. Sirtuin 1, AMP-activated protein kinase, and estrogen receptors represent the major molecules mediating the vascular effects of resveratrol.
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Li et al. (2019) conducted a review in Vascular function. Resveratrol was evaluated. Resveratrol improves vascular function and blood pressure through mechanisms including increased nitric oxide, reduced oxidative stress, and immune modulation.
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