Key result
Resveratrol prevents eNOS uncoupling and upregulates its expression in the endothelium and improves perivascular adipose tissue function, though a causal role for eNOS in PVAT remains unverified.
Resveratrol has established beneficial effects on endothelial eNOS, but its mechanism of action in improving perivascular adipose tissue function remains to be fully elucidated.
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Resveratrol's endothelial benefits support further clinical investigation; research must verify eNOS causality in perivascular adipose tissue.
Under physiological conditions, nitric oxide (NO) is produced in the vasculature mainly by the endothelial NO synthase (eNOS). Experiments using gene-disrupted mice have demonstrated that eNOS has antihypertensive, antithrombotic, and antiatherosclerotic effects. Recent studies show that eNOS is expressed not only in the endothelium but also in the perivascular adipose tissue (PVAT). Resveratrol prevents eNOS uncoupling and upregulates eNOS expression and activity. These effects of resveratrol are well established for the eNOS enzyme in the endothelium. Interestingly, resveratrol also improves PVAT function. However, a causal role for eNOS in the effects of resveratrol on PVAT function has not yet been verified and needs to be studied in the future.
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Xia et al. (2017) reported a review. Resveratrol was evaluated. Resveratrol prevents eNOS uncoupling and upregulates its expression in the endothelium and improves perivascular adipose tissue function, though a causal role for eNOS in PVAT remains unverified.
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